In 2018, the locality of Rustrel in the Vaucluse department had 675 inhabitants, a decrease of 7.91% compared to 2013 that contrasts with the upward trend of 1.79% of the department's population. After a peak of 977 inhabitants in 1860, during the industrial golden era of the village, and a dizzying drop to 268 inhabitants in 1962, the population of Rustrel has stabilized around 600-700 inhabitants since the 21st century. The municipality is part of the attraction area of Apt and has a low population density of 24 inhabitants per square kilometer.